Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells.

Song, Gang; Ming, Yanlin; Mao, Yubin; Bao, Shideng; Ouyang, Gaoliang

Song, Gang; Ming, Yanlin; Mao, Yubin; Bao, Shideng; Ouyang, Gaoliang.

Affiliation

Song G; Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China.

Exp Biol Med (Maywood) ; 233(12): 1537-45, 2008 Dec.

Article in En | MEDLINE | ID: mdl-18849546

Subject(s)

Integrin alphaVbeta3/metabolism; Osteopontin/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Stomach Neoplasms/metabolism; Apoptosis/drug effects; Cell Line, Tumor; Cell Survival/drug effects; Chromones/pharmacology; Clone Cells; Culture Media, Serum-Free; Curcumin/pharmacology; Enzyme Inhibitors/pharmacology; Humans; Morpholines/pharmacology; Osteopontin/genetics; Phosphatidylinositol 3-Kinases/metabolism; Phosphoinositide-3 Kinase Inhibitors; Recombinant Proteins/metabolism; Stomach Neoplasms/pathology; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Integrin alphaVbeta3 / Proto-Oncogene Proteins c-akt / Osteopontin Limits: Humans Language: En Journal: Exp Biol Med (Maywood) Journal subject: BIOLOGIA / FISIOLOGIA / MEDICINA Year: 2008 Type: Article Affiliation country: China

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