Liposomal encapsulation of 3'-azido-3'-deoxythymidine (AZT) results in decreased bone marrow toxicity and enhanced activity against murine AIDS-induced immunosuppression.

Phillips, N C; Skamene, E; Tsoukas, C

Phillips, N C; Skamene, E; Tsoukas, C.

Affiliation

Phillips NC; Montreal General Hospital Research Institute, McGill University, Quebec, Canada.

J Acquir Immune Defic Syndr (1988) ; 4(10): 959-66, 1991.

Article in En | MEDLINE | ID: mdl-1890605

Subject(s)

Bone Marrow/drug effects; Murine Acquired Immunodeficiency Syndrome/drug therapy; Zidovudine/administration & dosage; Animals; Capsules; Drug Carriers; Drug Synergism; Erythrocyte Count/drug effects; Female; Injections, Intravenous; Leukocyte Count/drug effects; Liposomes; Lymphocyte Activation/drug effects; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome/immunology; Spleen; Tissue Distribution; Zidovudine/metabolism; Zidovudine/toxicity

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Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow / Zidovudine / Murine Acquired Immunodeficiency Syndrome Limits: Animals Language: En Journal: J Acquir Immune Defic Syndr (1988) Journal subject: DOENCAS SEXUALMENTE TRANSMISSIVEIS / SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 1991 Type: Article Affiliation country: Canada

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