[Gene polymorphism of the endothelial nitric oxide synthase enzyme and pulmonary hypertension in patient with chronic obstructive pulmonary disease].
Zhonghua Jie He He Hu Xi Za Zhi
; 31(5): 335-40, 2008 May.
Article
in Zh
| MEDLINE
| ID: mdl-18953956
ABSTRACT
OBJECTIVE:
To investigate the relationship between the gene polymorphism of the endothelial nitric oxide synthase enzyme (eNOSG894T) with pulmonary hypertension of Chinese patient with chronic obstructive pulmonary disease (COPD).METHODS:
Fifty normal volunteers (29 male, 21 female, mean age 67 +/- 3) and 50 patients with COPD complicated by pulmonary hypertension (31 male, 19 female, mean age 69 +/- 10) were included in the study. Lung function, arterial blood gases, and echocardiographic examination were performed. The genotype of eNOSG894T was determined with PCR.RESULTS:
The frequencies of GT + FT genotype and T allele were significantly greater in the patients compared to the controls. The levels of NOx and NOx/ET were lower in the GT + T genotype [(48 +/- 8) micromol/L, (0.51 +/- 0.20)] than in the GG genotype [(60 +/- 24) micromol/L, (1.43 +/- 0.64)] of COPD. The level of ET was higher in the GT + TT genotype [(104 +/- 38) microg/L] than in the GG genotype [(50 +/- 26) microg/L] of COPD patients. The mean systolic pulmonary artery pressure was higher in the GT + TT genotype [(57 +/- 15) mm Hg, 1 mm Hg = 0.133 kPa] than in the GG genotype [(47 +/- 10) mm Hg] of COPD patients. In stepwise logistic regression analysis for predicting pulmonary artery pressure, the polymorphism of eNOS gene, the level of Nox and smoking were found to be independent variables.CONCLUSION:
The G894T polymorphism of eNOS gene is associated with pulmonary hypertension of COPD in a Chinese population. T allele may be involved in the etiology of pulmonary hypertension with COPD by reducing NO release of the endothelium.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pulmonary Disease, Chronic Obstructive
/
Nitric Oxide Synthase Type III
/
Hypertension, Pulmonary
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Zhonghua Jie He He Hu Xi Za Zhi
Year:
2008
Type:
Article
Affiliation country:
China