Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation.

Sontag, Jean-Marie; Nunbhakdi-Craig, Viyada; Montgomery, Lisa; Arning, Erland; Bottiglieri, Teodoro; Sontag, Estelle

Sontag, Jean-Marie; Nunbhakdi-Craig, Viyada; Montgomery, Lisa; Arning, Erland; Bottiglieri, Teodoro; Sontag, Estelle.

Affiliation

Sontag JM; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9073, USA. estelle.sontag@utsouthwestern.edu

J Neurosci ; 28(45): 11477-87, 2008 Nov 05.

Article in En | MEDLINE | ID: mdl-18987184

Subject(s)

Brain/metabolism; Down-Regulation/physiology; Folic Acid Deficiency/metabolism; Protein O-Methyltransferase/metabolism; Protein Phosphatase 2/metabolism; tau Proteins/metabolism; Animals; Brain/pathology; Carboxylic Ester Hydrolases/physiology; Cell Death/physiology; Cell Line, Transformed; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Serine/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein O-Methyltransferase / Brain / Down-Regulation / Tau Proteins / Protein Phosphatase 2 / Folic Acid Deficiency Limits: Animals Language: En Journal: J Neurosci Year: 2008 Type: Article Affiliation country: United States

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