Synthesis and biological evaluation of a 2-aryl polyhydroxylated pyrrolidine alkaloid-based library.

Tsou, En-Lun; Chen, Sih-Yu; Yang, Ming-Hsun; Wang, Shih-Chi; Cheng, Ting-Ren Rachel; Cheng, Wei-Chieh

Tsou, En-Lun; Chen, Sih-Yu; Yang, Ming-Hsun; Wang, Shih-Chi; Cheng, Ting-Ren Rachel; Cheng, Wei-Chieh.

Affiliation

Tsou EL; The Genomics Research Center, Academia Sinica, No. 128, Academia Road Sec. 2, Nankang District, Taipei 11529, Taiwan.

Bioorg Med Chem ; 16(24): 10198-204, 2008 Dec 15.

Article in En | MEDLINE | ID: mdl-19008111

Subject(s)

Alkaloids/chemical synthesis; Alkaloids/pharmacology; Glycoside Hydrolase Inhibitors; Pyrrolidines/chemical synthesis; Pyrrolidines/pharmacology; Alkaloids/chemistry; Drug Design; Inhibitory Concentration 50; Pyrrolidines/chemistry; Stereoisomerism; alpha-Glucosidases/metabolism; beta-Mannosidase/antagonists & inhibitors; beta-Mannosidase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Alkaloids / Glycoside Hydrolase Inhibitors Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: Taiwan

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