Preclinical toxicokinetic evaluation of phortress [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species.

Bradshaw, T D; Wren, J E; Bruce, M; Barrett, D A; Leong, C-O; Gaskell, M; Wright, E K; Farmer, P B; Henderson, C J; Wolf, R; Stevens, M F G

Bradshaw, T D; Wren, J E; Bruce, M; Barrett, D A; Leong, C-O; Gaskell, M; Wright, E K; Farmer, P B; Henderson, C J; Wolf, R; Stevens, M F G.

Affiliation

Bradshaw TD; School of Pharmacy, University of Nottingham, Nottingham, UK. tracey.bradshaw@nottingham.ac.uk

Pharmacology ; 83(2): 99-109, 2009.

Article in En | MEDLINE | ID: mdl-19088497

Subject(s)

Prodrugs/pharmacokinetics; Prodrugs/toxicity; Thiazoles/pharmacokinetics; Thiazoles/toxicity; Alkaline Phosphatase/blood; Animals; Body Weight; Cytochrome P-450 CYP1A1/metabolism; DNA Adducts/drug effects; DNA Adducts/pharmacokinetics; Drug Evaluation, Preclinical; Female; Genes, Reporter/drug effects; Kidney/drug effects; Kidney/metabolism; Kidney/pathology; Liver/drug effects; Liver/metabolism; Liver/pathology; Lung/drug effects; Lung/pathology; Male; Maximum Tolerated Dose; Mice; Mice, Inbred ICR; Organ Size; Rats; Rats, Sprague-Dawley; Thiazoles/blood; beta-Galactosidase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazoles / Prodrugs Limits: Animals Language: En Journal: Pharmacology Year: 2009 Type: Article Affiliation country: United kingdom

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