Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.

Thomas, Matthew; Docx, Cerys; Holmes, Alan M; Beach, Sarah; Duggan, Nicholas; England, Karen; Leblanc, Catherine; Lebret, Clemence; Schindler, Francis; Raza, Farheen; Walker, Christoph; Crosby, Alexi; Davies, Rachel J; Morrell, Nicholas W; Budd, David C

Thomas, Matthew; Docx, Cerys; Holmes, Alan M; Beach, Sarah; Duggan, Nicholas; England, Karen; Leblanc, Catherine; Lebret, Clemence; Schindler, Francis; Raza, Farheen; Walker, Christoph; Crosby, Alexi; Davies, Rachel J; Morrell, Nicholas W; Budd, David C.

Affiliation

Thomas M; Respiratory Disease Area, Novartis Horsham Research Centre, Horsham, West Sussex, UK.

Am J Pathol ; 174(2): 380-9, 2009 Feb.

Article in En | MEDLINE | ID: mdl-19116361

Subject(s)

Cell Proliferation; Hypertension, Pulmonary/enzymology; Muscle, Smooth, Vascular/metabolism; Protein Serine-Threonine Kinases/metabolism; Receptors, Transforming Growth Factor beta/metabolism; Animals; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II/metabolism; Cell Proliferation/drug effects; Disease Models, Animal; Disease Progression; Enzyme Inhibitors/pharmacology; Humans; Hypertension, Pulmonary/drug therapy; Hypertension, Pulmonary/pathology; Hypertrophy, Right Ventricular/drug therapy; Image Processing, Computer-Assisted; Imidazoles/pharmacology; Immunohistochemistry; Monocrotaline/toxicity; Muscle, Smooth, Vascular/drug effects; Protein Serine-Threonine Kinases/drug effects; Pulmonary Artery/drug effects; Pulmonary Artery/metabolism; Pulmonary Artery/pathology; Quinoxalines/pharmacology; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta/drug effects; Reverse Transcriptase Polymerase Chain Reaction; Smad3 Protein/metabolism; Transforming Growth Factor beta1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Receptors, Transforming Growth Factor beta / Cell Proliferation / Hypertension, Pulmonary / Muscle, Smooth, Vascular Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Am J Pathol Year: 2009 Type: Article Affiliation country: United kingdom

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