Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.

Gutierrez-Gonzalez, Lydia; Deheragoda, Maesha; Elia, George; Leedham, Simon J; Shankar, Arjun; Imber, Charles; Jankowski, Janusz A; Turnbull, Douglass M; Novelli, Marco; Wright, Nicholas A; McDonald, Stuart A C

Gutierrez-Gonzalez, Lydia; Deheragoda, Maesha; Elia, George; Leedham, Simon J; Shankar, Arjun; Imber, Charles; Jankowski, Janusz A; Turnbull, Douglass M; Novelli, Marco; Wright, Nicholas A; McDonald, Stuart A C.

Affiliation

Gutierrez-Gonzalez L; Histopathology Unit, London Research Institute, Cancer Research UK, London, UK.

J Pathol ; 217(4): 489-96, 2009 Mar.

Article in En | MEDLINE | ID: mdl-19156773

Subject(s)

DNA, Mitochondrial/genetics; Duodenum; Intestinal Mucosa/cytology; Mutation/genetics; Stem Cells/cytology; Aged; Biomarkers/analysis; Cell Lineage; Clone Cells/cytology; Clone Cells/enzymology; DNA Mutational Analysis; Electron Transport Complex IV/analysis; Epithelial Cells/cytology; Epithelial Cells/enzymology; Female; Histocytochemistry; Humans; Immunohistochemistry; Intestinal Mucosa/enzymology; Male; Middle Aged; Paneth Cells/cytology; Paneth Cells/enzymology; Stem Cells/enzymology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / DNA, Mitochondrial / Duodenum / Intestinal Mucosa / Mutation Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: J Pathol Year: 2009 Type: Article Affiliation country: United kingdom

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