Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus.

Heupel, Wolfgang-Moritz; Müller, Thomas; Efthymiadis, Athina; Schmidt, Enno; Drenckhahn, Detlev; Waschke, Jens

Heupel, Wolfgang-Moritz; Müller, Thomas; Efthymiadis, Athina; Schmidt, Enno; Drenckhahn, Detlev; Waschke, Jens.

Affiliation

Heupel WM; Department of Anatomy and Cell Biology, University of Würzburg, Koellikerstr. 6, D-97070 Würzburg.

J Biol Chem ; 284(13): 8589-95, 2009 Mar 27.

Article in En | MEDLINE | ID: mdl-19164289

Subject(s)

Acantholysis/immunology; Autoantibodies/immunology; Desmoglein 3/immunology; Immunoglobulin G/immunology; Pemphigus/immunology; Peptides/pharmacology; Acantholysis/drug therapy; Acantholysis/genetics; Acantholysis/pathology; Cell Line; Desmoglein 1/antagonists & inhibitors; Desmoglein 1/chemistry; Desmoglein 1/genetics; Desmoglein 1/immunology; Desmoglein 3/antagonists & inhibitors; Desmoglein 3/genetics; Humans; Keratinocytes/immunology; Keratinocytes/pathology; Models, Molecular; Pemphigus/drug therapy; Pemphigus/genetics; Pemphigus/pathology; Peptides/chemistry; Peptides/genetics; Peptides/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Autoantibodies / Immunoglobulin G / Acantholysis / Pemphigus / Desmoglein 3 Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2009 Type: Article

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