Bone marrow deficient in IFN-{gamma} signaling selectively reverses GVHD-associated immunosuppression and enhances a tumor-specific GVT effect.

Capitini, Christian M; Herby, Sarah; Milliron, Matthew; Anver, Miriam R; Mackall, Crystal L; Fry, Terry J

Capitini, Christian M; Herby, Sarah; Milliron, Matthew; Anver, Miriam R; Mackall, Crystal L; Fry, Terry J.

Affiliation

Capitini CM; Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. capitinic@mail.nih.gov

Blood ; 113(20): 5002-9, 2009 May 14.

Article in En | MEDLINE | ID: mdl-19258593

Subject(s)

Bone Marrow Transplantation/physiology; Graft vs Host Disease/prevention & control; Graft vs Tumor Effect/genetics; Interferon-gamma/metabolism; Receptors, Interferon/genetics; Animals; Bone Marrow Transplantation/methods; Female; Graft vs Host Disease/complications; Graft vs Host Disease/genetics; Graft vs Tumor Effect/immunology; Immunosuppression Therapy/adverse effects; Interferon-gamma/physiology; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Receptors, Interferon/metabolism; Signal Transduction/genetics; Signal Transduction/immunology; Substrate Specificity/genetics; Substrate Specificity/immunology; Transplantation Conditioning/methods; Tumor Cells, Cultured; Tumor Escape/genetics; Tumor Escape/immunology; Interferon gamma Receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow Transplantation / Interferon-gamma / Receptors, Interferon / Graft vs Tumor Effect / Graft vs Host Disease Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Blood Year: 2009 Type: Article Affiliation country: United States

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