Effects of double combinations of amantadine, oseltamivir, and ribavirin on influenza A (H5N1) virus infections in cell culture and in mice.

Smee, Donald F; Hurst, Brett L; Wong, Min-Hui; Bailey, Kevin W; Morrey, John D

Smee, Donald F; Hurst, Brett L; Wong, Min-Hui; Bailey, Kevin W; Morrey, John D.

Affiliation

Smee DF; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, UT 84322-5600, USA. don.smee@usu.edu

Antimicrob Agents Chemother ; 53(5): 2120-8, 2009 May.

Article in En | MEDLINE | ID: mdl-19273672

Subject(s)

Amantadine; Antiviral Agents; Disease Models, Animal; Influenza A Virus, H5N1 Subtype/drug effects; Orthomyxoviridae Infections/drug therapy; Oseltamivir; Ribavirin; Amantadine/administration & dosage; Amantadine/pharmacology; Amantadine/therapeutic use; Animals; Antiviral Agents/administration & dosage; Antiviral Agents/pharmacology; Antiviral Agents/therapeutic use; Cell Line; Drug Interactions; Drug Resistance, Viral/genetics; Drug Therapy, Combination; Humans; Influenza A Virus, H5N1 Subtype/genetics; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests/methods; Orthomyxoviridae Infections/virology; Oseltamivir/administration & dosage; Oseltamivir/pharmacology; Oseltamivir/therapeutic use; Ribavirin/administration & dosage; Ribavirin/pharmacology; Ribavirin/therapeutic use; Specific Pathogen-Free Organisms; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Ribavirin / Amantadine / Orthomyxoviridae Infections / Disease Models, Animal / Influenza A Virus, H5N1 Subtype / Oseltamivir Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2009 Type: Article Affiliation country: United States

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