Prostate-specific antigen is a "chymotrypsin-like" serine protease with unique P1 substrate specificity.

LeBeau, Aaron M; Singh, Pratap; Isaacs, John T; Denmeade, Samuel R

LeBeau, Aaron M; Singh, Pratap; Isaacs, John T; Denmeade, Samuel R.

Affiliation

LeBeau AM; Department of Pharmacology and Molecular Sciences, The Johns Hopkins University, Baltimore, Maryland 21231, USA.

Biochemistry ; 48(15): 3490-6, 2009 Apr 21.

Article in En | MEDLINE | ID: mdl-19281249

Subject(s)

Chymotrypsin/metabolism; Enzyme Inhibitors/chemistry; Peptides/metabolism; Prostate-Specific Antigen/metabolism; Structural Homology, Protein; Aldehydes/antagonists & inhibitors; Aldehydes/metabolism; Amino Acid Motifs; Animals; Cattle; Chymotrypsin/antagonists & inhibitors; Chymotrypsin/chemistry; Enzyme Inhibitors/chemical synthesis; Glutamine/antagonists & inhibitors; Glutamine/metabolism; Humans; Peptides/antagonists & inhibitors; Prostate-Specific Antigen/antagonists & inhibitors; Prostate-Specific Antigen/chemistry; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Chymotrypsin / Prostate-Specific Antigen / Structural Homology, Protein / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2009 Type: Article Affiliation country: United States

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