Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-epi-paclitaxel.

Zhang, Y-Y; Liu, Y; Zhang, J-W; Ge, G-B; Wang, L-M; Sun, J; Yang, L

Zhang, Y-Y; Liu, Y; Zhang, J-W; Ge, G-B; Wang, L-M; Sun, J; Yang, L.

Affiliation

Zhang YY; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

Xenobiotica ; 39(4): 283-92, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19350451

Subject(s)

Cytochrome P-450 CYP3A/metabolism; Microsomes, Liver/metabolism; Taxoids/metabolism; Taxoids/pharmacokinetics; Aryl Hydrocarbon Hydroxylases/metabolism; Biotransformation/physiology; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C8; Humans; Inhibitory Concentration 50; Isoenzymes/metabolism; Kinetics; Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Taxoids/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Taxoids / Cytochrome P-450 CYP3A Limits: Humans Language: En Journal: Xenobiotica Year: 2009 Type: Article Affiliation country: China

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