Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.

Wei, Jun; Kitada, Shinichi; Rega, Michele F; Emdadi, Aras; Yuan, Hongbin; Cellitti, Jason; Stebbins, John L; Zhai, Dayong; Sun, Jiazhi; Yang, Li; Dahl, Russell; Zhang, Ziming; Wu, Bainan; Wang, Si; Reed, Tyler A; Wang, Hong-Gang; Lawrence, Nicholas; Sebti, Said; Reed, John C; Pellecchia, Maurizio

Wei, Jun; Kitada, Shinichi; Rega, Michele F; Emdadi, Aras; Yuan, Hongbin; Cellitti, Jason; Stebbins, John L; Zhai, Dayong; Sun, Jiazhi; Yang, Li; Dahl, Russell; Zhang, Ziming; Wu, Bainan; Wang, Si; Reed, Tyler A; Wang, Hong-Gang; Lawrence, Nicholas; Sebti, Said; Reed, John C; Pellecchia, Maurizio.

Affiliation

Wei J; Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 90237, USA.

Mol Cancer Ther ; 8(4): 904-13, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19372563

Subject(s)

Gossypol/analogs & derivatives; Lung Neoplasms/drug therapy; Lymphoma/drug therapy; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors; Proto-Oncogene Proteins c-bcl-2/metabolism; Animals; Apoptosis Regulatory Proteins/metabolism; Bcl-2-Like Protein 11; Cell Survival/drug effects; Female; Fluorescence Polarization; Gossypol/chemical synthesis; Gossypol/chemistry; Gossypol/pharmacology; Humans; Lung Neoplasms/metabolism; Lung Neoplasms/pathology; Lymphoma/metabolism; Lymphoma/pathology; Magnetic Resonance Spectroscopy; Male; Membrane Proteins/metabolism; Membranes, Artificial; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Transgenic; Microsomes, Liver; Models, Molecular; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/genetics; Rats; Tumor Cells, Cultured; bcl-2 Homologous Antagonist-Killer Protein/physiology; bcl-2-Associated X Protein/physiology; bcl-X Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gossypol / Proto-Oncogene Proteins c-bcl-2 / Lung Neoplasms / Lymphoma Type of study: Prognostic_studies Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2009 Type: Article Affiliation country: United States

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