Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

Chen, Hainan; Gu, Xueying; Su, I-hsin; Bottino, Rita; Contreras, Juan L; Tarakhovsky, Alexander; Kim, Seung K

Chen, Hainan; Gu, Xueying; Su, I-hsin; Bottino, Rita; Contreras, Juan L; Tarakhovsky, Alexander; Kim, Seung K.

Affiliation

Chen H; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

Genes Dev ; 23(8): 975-85, 2009 Apr 15.

Article in En | MEDLINE | ID: mdl-19390090

Subject(s)

Cyclin-Dependent Kinase Inhibitor p16/metabolism; Diabetes Mellitus/metabolism; Gene Expression Regulation; Histone-Lysine N-Methyltransferase/metabolism; Insulin-Secreting Cells/metabolism; Aging/metabolism; Animals; Antibiotics, Antineoplastic/pharmacology; Cell Proliferation/drug effects; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16/genetics; Enhancer of Zeste Homolog 2 Protein; Female; Gene Deletion; Gene Expression Regulation/drug effects; Histones/metabolism; Humans; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/drug effects; Male; Mice; Mice, Inbred C57BL; Polycomb Repressive Complex 2; Streptozocin/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Histone-Lysine N-Methyltransferase / Cyclin-Dependent Kinase Inhibitor p16 / Diabetes Mellitus / Insulin-Secreting Cells Limits: Animals / Female / Humans / Male Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2009 Type: Article Affiliation country: United States

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