Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin.

Rojo, Federico; González-Navarrete, Irene; Bragado, Rafael; Dalmases, Alba; Menéndez, Silvia; Cortes-Sempere, Maria; Suárez, Cristina; Oliva, Cristina; Servitja, Sonia; Rodriguez-Fanjul, Vanesa; Sánchez-Pérez, Isabel; Campas, Clara; Corominas, Josep Maria; Tusquets, Ignasi; Bellosillo, Beatriz; Serrano, Sergi; Perona, Rosario; Rovira, Ana; Albanell, Joan

Rojo, Federico; González-Navarrete, Irene; Bragado, Rafael; Dalmases, Alba; Menéndez, Silvia; Cortes-Sempere, Maria; Suárez, Cristina; Oliva, Cristina; Servitja, Sonia; Rodriguez-Fanjul, Vanesa; Sánchez-Pérez, Isabel; Campas, Clara; Corominas, Josep Maria; Tusquets, Ignasi; Bellosillo, Beatriz; Serrano, Sergi; Perona, Rosario; Rovira, Ana; Albanell, Joan.

Affiliation

Rojo F; Cancer Research Program, IMIM-Hospital del Mar, Barcelona, Spain.

Clin Cancer Res ; 15(10): 3530-9, 2009 May 15.

Article in En | MEDLINE | ID: mdl-19417026

Subject(s)

Breast Neoplasms/pathology; Doxorubicin/pharmacology; Dual Specificity Phosphatase 1/metabolism; Antibiotics, Antineoplastic/pharmacology; Blotting, Western; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Cell Line, Tumor; Cluster Analysis; Dual Specificity Phosphatase 1/genetics; Extracellular Signal-Regulated MAP Kinases/metabolism; Gene Expression Regulation, Enzymologic/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Humans; Immunohistochemistry; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases/metabolism; Kaplan-Meier Estimate; Neoplasm Recurrence, Local; Phosphorylation/drug effects; Predictive Value of Tests; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Doxorubicin / Dual Specificity Phosphatase 1 Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2009 Type: Article Affiliation country: Spain

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