Practical synthesis of a potent bradykinin B(1) antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide.

O'Shea, Paul D; Gauvreau, Danny; Gosselin, Francis; Hughes, Greg; Nadeau, Christian; Roy, Amélie; Shultz, C Scott

O'Shea, Paul D; Gauvreau, Danny; Gosselin, Francis; Hughes, Greg; Nadeau, Christian; Roy, Amélie; Shultz, C Scott.

Affiliation

O'Shea PD; Department of Process Research, Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe-Claire-DorVal, Québec H9R 4P8, Canada. paul_oshea@merck.com

J Org Chem ; 74(12): 4547-53, 2009 Jun 19.

Article in En | MEDLINE | ID: mdl-19456171

Subject(s)

Amides/chemical synthesis; Bradykinin B1 Receptor Antagonists; Pyridines/chemical synthesis; Amides/chemistry; Amides/pharmacology; Amines/chemical synthesis; Amines/chemistry; Azoles/chemical synthesis; Azoles/chemistry; Boronic Acids/chemical synthesis; Boronic Acids/chemistry; Hydrocarbons, Fluorinated/chemical synthesis; Hydrocarbons, Fluorinated/chemistry; Hydrogenation; Methylation; Pyridines/chemistry; Pyridines/pharmacology; Stereoisomerism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Bradykinin B1 Receptor Antagonists / Amides Language: En Journal: J Org Chem Year: 2009 Type: Article Affiliation country: Canada

Fulltext

XML

PubMed Links

Search on Google