Evidence of inheritance of intrahepatic portosystemic shunts in Irish Wolfhounds.
J Vet Intern Med
; 23(4): 950-2, 2009.
Article
in En
| MEDLINE
| ID: mdl-19496918
ABSTRACT
BACKGROUND:
The etiogenesis of congenital portosystemic shunt in dogs is not understood. In Irish Wolfhounds, intrahepatic portosystemic shunt (IHPSS) is thought to be hereditary, but the mode of inheritance is unknown.OBJECTIVES:
To document the genetic background and investigate the potential mode of inheritance of IHPSS in Irish Wolfhounds. ANIMALS Three mature, privately owned, affected siblings and their progeny produced in 2 litters.METHODS:
Prospective, observational study. Two test matings of 1 affected sire with 2 of his affected sisters were used to determine the inheritance pattern. Affection status was determined by measuring venous blood ammonia concentrations, detection of the shunt by ultrasonography and confirmation during surgical attenuation of the intrahepatic shunting vessel.RESULTS:
In 1 litter of 5 pups all had an IHPSS. In the other litter 5 of 11 pups were affected. Both left- and right-sided shunts occurred in both litters. No sex predisposition was evident among affected dogs. CONCLUSIONS AND CLINICAL IMPORTANCE Our results show that IHPSS in Irish Wolfhounds is a familial disorder that is likely genetic. It is unlikely that the mode of inheritance is monogenic. A digenic, triallelic trait could explain the observed occurrence of IHPSS but other modes of inheritance cannot be excluded.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Portal System
/
Dog Diseases
Type of study:
Observational_studies
Limits:
Animals
Language:
En
Journal:
J Vet Intern Med
Journal subject:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Year:
2009
Type:
Article
Affiliation country:
Netherlands