Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

Hart, Terance; Macias, Alba T; Benwell, Karen; Brooks, Teresa; D'Alessandro, Jalanie; Dokurno, Pawel; Francis, Geraint; Gibbons, Ben; Haymes, Timothy; Kennett, Guy; Lightowler, Sean; Mansell, Howard; Matassova, Natalia; Misra, Anil; Padfield, Anthony; Parsons, Rachel; Pratt, Robert; Robertson, Alan; Walls, Steven; Wong, Melanie; Roughley, Stephen

Hart, Terance; Macias, Alba T; Benwell, Karen; Brooks, Teresa; D'Alessandro, Jalanie; Dokurno, Pawel; Francis, Geraint; Gibbons, Ben; Haymes, Timothy; Kennett, Guy; Lightowler, Sean; Mansell, Howard; Matassova, Natalia; Misra, Anil; Padfield, Anthony; Parsons, Rachel; Pratt, Robert; Robertson, Alan; Walls, Steven; Wong, Melanie; Roughley, Stephen.

Affiliation

Hart T; Vernalis (R&D) Ltd, Granta Park, Cambridge CB21 6GB, UK. t.hart@vernalis.com

Bioorg Med Chem Lett ; 19(15): 4241-4, 2009 Aug 01.

Article in En | MEDLINE | ID: mdl-19515560

Subject(s)

Amidohydrolases/antagonists & inhibitors; Amidohydrolases/chemistry; Azetidines/chemistry; Azetidines/chemical synthesis; Enzyme Inhibitors/chemical synthesis; Piperidines/chemical synthesis; Urea/chemistry; Animals; Azetidines/pharmacology; Catalysis; Chemistry, Pharmaceutical/methods; Drug Design; Enzyme Inhibitors/pharmacology; Humans; Mice; Mice, Knockout; Models, Chemical; Piperidines/pharmacology; Rats; Receptor, Cannabinoid, CB1/chemistry; Stereoisomerism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Azetidines / Urea / Enzyme Inhibitors / Amidohydrolases Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United kingdom

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