Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.

Jarrom, David; Jaberipour, Mansooreh; Guise, Christopher P; Daff, Simon; White, Scott A; Searle, Peter F; Hyde, Eva I

Jarrom, David; Jaberipour, Mansooreh; Guise, Christopher P; Daff, Simon; White, Scott A; Searle, Peter F; Hyde, Eva I.

Affiliation

Jarrom D; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Biochemistry ; 48(32): 7665-72, 2009 Aug 18.

Article in En | MEDLINE | ID: mdl-19580253

Subject(s)

Antineoplastic Agents/metabolism; Aziridines/metabolism; Escherichia coli Proteins/metabolism; Escherichia coli/enzymology; Mutation; Nitroreductases/metabolism; Prodrugs/metabolism; Anti-Infective Agents/chemistry; Anti-Infective Agents/metabolism; Antineoplastic Agents/chemistry; Antineoplastic Agents/therapeutic use; Aziridines/chemistry; Aziridines/therapeutic use; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Models, Molecular; Molecular Structure; Nitrofurazone/chemistry; Nitrofurazone/metabolism; Nitroreductases/genetics; Prodrugs/chemistry; Prodrugs/therapeutic use; Protein Structure, Tertiary; Vitamin K 3/chemistry; Vitamin K 3/metabolism; Vitamins/chemistry; Vitamins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aziridines / Nitroreductases / Prodrugs / Escherichia coli Proteins / Escherichia coli / Mutation / Antineoplastic Agents Language: En Journal: Biochemistry Year: 2009 Type: Article Affiliation country: United kingdom

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