Periplocoside A prevents experimental autoimmune encephalomyelitis by suppressing IL-17 production and inhibits differentiation of Th17 cells.

Zhang, Jing; Ni, Jia; Chen, Zhen-hua; Li, Xin; Zhang, Ru-jun; Tang, Wei; Zhao, Wei-min; Yang, Yi-fu; Zuo, Jian-ping

Zhang, Jing; Ni, Jia; Chen, Zhen-hua; Li, Xin; Zhang, Ru-jun; Tang, Wei; Zhao, Wei-min; Yang, Yi-fu; Zuo, Jian-ping.

Affiliation

Zhang J; State Key Laboratory of New Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Acta Pharmacol Sin ; 30(8): 1144-52, 2009 Aug.

Article in En | MEDLINE | ID: mdl-19597527

Subject(s)

Drugs, Chinese Herbal/therapeutic use; Encephalomyelitis, Autoimmune, Experimental/prevention & control; Glycosides/therapeutic use; Interleukin-17/immunology; Pregnenes/therapeutic use; T-Lymphocytes/drug effects; Animals; Cell Differentiation/drug effects; Drugs, Chinese Herbal/isolation & purification; Encephalomyelitis, Autoimmune, Experimental/chemically induced; Encephalomyelitis, Autoimmune, Experimental/immunology; Female; Glycoproteins; Glycosides/isolation & purification; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Periploca/chemistry; Pregnenes/isolation & purification; Spinal Cord/drug effects; Spinal Cord/immunology; T-Lymphocytes/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnenes / Drugs, Chinese Herbal / T-Lymphocytes / Interleukin-17 / Encephalomyelitis, Autoimmune, Experimental / Glycosides Limits: Animals Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2009 Type: Article Affiliation country: China

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