Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways.

Ouyang, Gaoliang; Yao, Luming; Ruan, Kai; Song, Gang; Mao, Yubin; Bao, Shideng

Ouyang, Gaoliang; Yao, Luming; Ruan, Kai; Song, Gang; Mao, Yubin; Bao, Shideng.

Affiliation

Ouyang G; Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China. oygldz@yahoo.com.cn

Cell Biol Int ; 33(12): 1237-44, 2009 Dec.

Article in En | MEDLINE | ID: mdl-19732843

Subject(s)

Anticarcinogenic Agents/pharmacology; Apoptosis/drug effects; Cell Cycle/drug effects; DNA Damage/drug effects; Genistein/pharmacology; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/genetics; Ovarian Neoplasms/pathology; Signal Transduction/drug effects; Apoptosis/genetics; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein/metabolism; CDC2 Protein Kinase; Cell Cycle/genetics; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Checkpoint Kinase 1; Checkpoint Kinase 2; Cyclin B/metabolism; Cyclin-Dependent Kinases; DNA-Binding Proteins/metabolism; Female; Humans; Ovarian Neoplasms/metabolism; Phosphorylation; Protein Kinases/metabolism; Protein Serine-Threonine Kinases/metabolism; Signal Transduction/genetics; Tumor Suppressor Proteins/metabolism; bcl-2-Associated X Protein/metabolism; bcl-X Protein/metabolism; cdc25 Phosphatases/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / DNA Damage / Signal Transduction / Cell Cycle / Anticarcinogenic Agents / Apoptosis / Genistein Limits: Female / Humans Language: En Journal: Cell Biol Int Year: 2009 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google