Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.

Meilinger, Daniela; Fellinger, Karin; Bultmann, Sebastian; Rothbauer, Ulrich; Bonapace, Ian Marc; Klinkert, Wolfgang E F; Spada, Fabio; Leonhardt, Heinrich

Meilinger, Daniela; Fellinger, Karin; Bultmann, Sebastian; Rothbauer, Ulrich; Bonapace, Ian Marc; Klinkert, Wolfgang E F; Spada, Fabio; Leonhardt, Heinrich.

Affiliation

Meilinger D; Department of Biology II, Center for Integrated Protein Science Munich (CIPSM), Ludwig Maximilians University Munich, Grosshaderner Street 2, 82152 Planegg-Martinsried, Germany.

EMBO Rep ; 10(11): 1259-64, 2009 Nov.

Article in En | MEDLINE | ID: mdl-19798101

Subject(s)

Cytomegalovirus/genetics; DNA (Cytosine-5-)-Methyltransferases/metabolism; Embryonic Stem Cells/cytology; Epigenesis, Genetic; Nuclear Proteins/chemistry; Promoter Regions, Genetic; Animals; CCAAT-Enhancer-Binding Proteins/metabolism; Cricetinae; Cricetulus; DNA Methylation; DNA Methyltransferase 3A; Gene Silencing; Humans; Methyltransferases/chemistry; Mice; Protein Structure, Tertiary; Ubiquitin-Protein Ligases; DNA Methyltransferase 3B

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Promoter Regions, Genetic / Cytomegalovirus / Epigenesis, Genetic / DNA (Cytosine-5-)-Methyltransferases / Embryonic Stem Cells Limits: Animals / Humans Language: En Journal: EMBO Rep Journal subject: BIOLOGIA MOLECULAR Year: 2009 Type: Article Affiliation country: Germany

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