Hypophysectomy for a dog with coexisting Cushing's disease and diabetes mellitus.

Ishino, Hirokazu; Hara, Yasushi; Teshima, Takahiro; Tanaka, Shigeki; Takekoshi, Susumu; Nezu, Yoshinori; Harada, Yasuji; Yogo, Takuya; Sako, Toshinori; Koyama, Hidekazu; Teramoto, Akira; Osamura, Robert Y; Tagawa, Masahiro

Ishino, Hirokazu; Hara, Yasushi; Teshima, Takahiro; Tanaka, Shigeki; Takekoshi, Susumu; Nezu, Yoshinori; Harada, Yasuji; Yogo, Takuya; Sako, Toshinori; Koyama, Hidekazu; Teramoto, Akira; Osamura, Robert Y; Tagawa, Masahiro.

Affiliation

Ishino H; Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan. hiro-ish@pp.iij4u.or.jp

J Vet Med Sci ; 72(3): 343-8, 2010 Mar.

Article in En | MEDLINE | ID: mdl-19952515

ABSTRACT

ABSTRACT

An 11-year-old male mixed breed dog diagnosed with Cushing's disease and diabetes mellitus was treated by hypophysectomy. After surgery, the hypercortisolemia disappeared and the diabetes status improved. The insulin requirement to control hyperglycemia gradually decreased. At 12 weeks after surgery, there was no requirement for insulin and we suspected the diabetes was completely resolved. In the present case, diabetes mellitus seems to be secondary to Cushing's disease. In conclusion, this mixed breed dog with coexisting Cushing's disease and diabetes mellitus is the first case showing the effectiveness of hypophysectomy to treat diabetes mellitus secondary to Cushing's disease in dogs.

Subject(s)

Diabetes Complications/veterinary; Diabetes Mellitus/veterinary; Hypophysectomy/veterinary; Pituitary ACTH Hypersecretion/veterinary; 3-Hydroxysteroid Dehydrogenases/antagonists & inhibitors; Adrenocorticotropic Hormone/immunology; Animals; Blood Glucose/drug effects; Blood Glucose/metabolism; Diabetes Complications/surgery; Diabetes Mellitus/drug therapy; Dihydrotestosterone/analogs & derivatives; Dihydrotestosterone/therapeutic use; Dogs; Dose-Response Relationship, Drug; Hypoglycemic Agents/therapeutic use; Hypophysectomy/methods; Insulin/therapeutic use; Male; Pituitary ACTH Hypersecretion/complications; Pituitary ACTH Hypersecretion/surgery; Pituitary Gland/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Pituitary ACTH Hypersecretion / Diabetes Complications / Diabetes Mellitus / Hypophysectomy Limits: Animals Language: En Journal: J Vet Med Sci Journal subject: MEDICINA VETERINARIA Year: 2010 Type: Article Affiliation country: Japan

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