TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.

Liang, M-C; Ma, J; Chen, L; Kozlowski, P; Qin, W; Li, D; Goto, J; Shimamura, T; Hayes, D N; Meyerson, M; Kwiatkowski, D J; Wong, K-K

Liang, M-C; Ma, J; Chen, L; Kozlowski, P; Qin, W; Li, D; Goto, J; Shimamura, T; Hayes, D N; Meyerson, M; Kwiatkowski, D J; Wong, K-K.

Affiliation

Liang MC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Oncogene ; 29(11): 1588-97, 2010 Mar 18.

Article in En | MEDLINE | ID: mdl-19966866

Subject(s)

Lung Neoplasms/prevention & control; Proto-Oncogene Proteins p21(ras)/genetics; Sirolimus/pharmacology; Tumor Suppressor Proteins/genetics; Animals; Antibiotics, Antineoplastic/pharmacology; Apoptosis; Bronchi/drug effects; Bronchi/metabolism; Bronchi/pathology; Cell Line; Enzyme Activation; Humans; Immunoblotting; In Situ Nick-End Labeling; Kaplan-Meier Estimate; Loss of Heterozygosity; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Multiprotein Complexes; Mutation; Proteins; Proto-Oncogene Proteins p21(ras)/metabolism; TOR Serine-Threonine Kinases; Transcription Factors/metabolism; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins p21(ras) / Sirolimus / Tumor Suppressor Proteins / Lung Neoplasms Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2010 Type: Article Affiliation country: United States

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