Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation.

Dansette, P M; Amar, C; Valadon, P; Pons, C; Beaune, P H; Mansuy, D

Dansette, P M; Amar, C; Valadon, P; Pons, C; Beaune, P H; Mansuy, D.

Affiliation

Dansette PM; Unité de Recherche Associée au CNRS (URA 400), Université René Descartes, Paris, France.

Biochem Pharmacol ; 41(4): 553-60, 1991 Feb 15.

Article in En | MEDLINE | ID: mdl-1997003

Subject(s)

Cytochrome P-450 Enzyme System/physiology; Isoenzymes/physiology; Mephenytoin/metabolism; Microsomes, Liver/metabolism; Ticrynafen/metabolism; Biotransformation; Female; Humans; Hydroxylation; In Vitro Techniques; Male

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Collection: 01-internacional Database: MEDLINE Main subject: Ticrynafen / Microsomes, Liver / Cytochrome P-450 Enzyme System / Isoenzymes / Mephenytoin Limits: Female / Humans / Male Language: En Journal: Biochem Pharmacol Year: 1991 Type: Article Affiliation country: France

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