CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes.

Cao, Y-F; Zhang, Y-Y; Li, J; Ge, G-B; Hu, D; Liu, H-X; Huang, T; Wang, Y-C; Fang, Z-Z; Sun, D-X; Huo, H; Yin, J; Yang, L

Cao, Y-F; Zhang, Y-Y; Li, J; Ge, G-B; Hu, D; Liu, H-X; Huang, T; Wang, Y-C; Fang, Z-Z; Sun, D-X; Huo, H; Yin, J; Yang, L.

Affiliation

Cao YF; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.

Xenobiotica ; 40(1): 38-47, 2010 Jan.

Article in En | MEDLINE | ID: mdl-20001672

Subject(s)

Cyclooctanes/pharmacokinetics; Cytochrome P-450 CYP3A/metabolism; Lignans/pharmacokinetics; Metabolic Networks and Pathways; Microsomes, Liver/enzymology; Polycyclic Compounds/pharmacokinetics; Animals; Catalysis/drug effects; Chromatography, High Pressure Liquid; Cyclooctanes/chemistry; Cytochrome P-450 CYP3A Inhibitors; Humans; Ketoconazole/pharmacology; Lignans/chemistry; Mass Spectrometry; Microsomes, Liver/drug effects; Polycyclic Compounds/chemistry; Rats; Swine; Swine, Miniature; Troleandomycin/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycyclic Compounds / Microsomes, Liver / Lignans / Cyclooctanes / Cytochrome P-450 CYP3A / Metabolic Networks and Pathways Limits: Animals / Humans Language: En Journal: Xenobiotica Year: 2010 Type: Article Affiliation country: China

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