Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

Lin, Xian; Parisiadou, Loukia; Gu, Xing-Long; Wang, Lizhen; Shim, Hoon; Sun, Lixin; Xie, Chengsong; Long, Cai-Xia; Yang, Wan-Jou; Ding, Jinhui; Chen, Zsu Zsu; Gallant, Paul E; Tao-Cheng, Jung-Hwa; Rudow, Gay; Troncoso, Juan C; Liu, Zhihua; Li, Zheng; Cai, Huaibin

Lin, Xian; Parisiadou, Loukia; Gu, Xing-Long; Wang, Lizhen; Shim, Hoon; Sun, Lixin; Xie, Chengsong; Long, Cai-Xia; Yang, Wan-Jou; Ding, Jinhui; Chen, Zsu Zsu; Gallant, Paul E; Tao-Cheng, Jung-Hwa; Rudow, Gay; Troncoso, Juan C; Liu, Zhihua; Li, Zheng; Cai, Huaibin.

Affiliation

Lin X; Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

Neuron ; 64(6): 807-27, 2009 Dec 24.

Article in En | MEDLINE | ID: mdl-20064389

Subject(s)

Brain/metabolism; Nerve Degeneration/metabolism; Parkinson Disease/metabolism; Protein Serine-Threonine Kinases/metabolism; alpha-Synuclein/metabolism; Animals; Brain/physiopathology; Disease Progression; Gene Expression Regulation/genetics; Genetic Predisposition to Disease/genetics; Golgi Apparatus/metabolism; Golgi Apparatus/ultrastructure; Inclusion Bodies/genetics; Inclusion Bodies/metabolism; Inclusion Bodies/pathology; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Mice, Knockout; Mice, Transgenic; Microtubules/metabolism; Microtubules/ultrastructure; Mutation/genetics; Nerve Degeneration/genetics; Nerve Degeneration/physiopathology; Neurons/metabolism; Neurons/pathology; Parkinson Disease/genetics; Parkinson Disease/physiopathology; Protein Serine-Threonine Kinases/genetics; alpha-Synuclein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Brain / Protein Serine-Threonine Kinases / Alpha-Synuclein / Nerve Degeneration Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2009 Type: Article Affiliation country: United States

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