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Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.
Juliana, Christine; Fernandes-Alnemri, Teresa; Wu, Jianghong; Datta, Pinaki; Solorzano, Leobaldo; Yu, Je-Wook; Meng, Rong; Quong, Andrew A; Latz, Eicke; Scott, Charles P; Alnemri, Emad S.
Affiliation
  • Juliana C; Departments of Biochemistry and Molecular Biology, Philadelphia, Pennsylvania 19107.
  • Fernandes-Alnemri T; Departments of Biochemistry and Molecular Biology, Philadelphia, Pennsylvania 19107.
  • Wu J; Departments of Biochemistry and Molecular Biology, Philadelphia, Pennsylvania 19107.
  • Datta P; Departments of Biochemistry and Molecular Biology, Philadelphia, Pennsylvania 19107.
  • Solorzano L; Departments of Biochemistry and Molecular Biology, Philadelphia, Pennsylvania 19107.
  • Yu JW; Departments of Biochemistry and Molecular Biology, Philadelphia, Pennsylvania 19107.
  • Meng R; Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
  • Quong AA; Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
  • Latz E; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605; Institute of Innate Immunity, University of Bonn, D53012 Bonn, Germany.
  • Scott CP; Departments of Biochemistry and Molecular Biology, Philadelphia, Pennsylvania 19107.
  • Alnemri ES; Departments of Biochemistry and Molecular Biology, Philadelphia, Pennsylvania 19107. Electronic address: E_Alnemri@mail.jci.tju.edu.
J Biol Chem ; 285(13): 9792-9802, 2010 Mar 26.
Article in En | MEDLINE | ID: mdl-20093358
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Sulfones / Inflammation / Anti-Inflammatory Agents / Nitriles Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2010 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Sulfones / Inflammation / Anti-Inflammatory Agents / Nitriles Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2010 Type: Article