Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.

Purushothaman, Anurag; Uyama, Toru; Kobayashi, Fumi; Yamada, Shuhei; Sugahara, Kazuyuki; Rapraeger, Alan C; Sanderson, Ralph D

Purushothaman, Anurag; Uyama, Toru; Kobayashi, Fumi; Yamada, Shuhei; Sugahara, Kazuyuki; Rapraeger, Alan C; Sanderson, Ralph D.

Affiliation

Purushothaman A; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Blood ; 115(12): 2449-57, 2010 Mar 25.

Article in En | MEDLINE | ID: mdl-20097882

Subject(s)

Glucuronidase/metabolism; Multiple Myeloma; Neovascularization, Pathologic/metabolism; Neovascularization, Pathologic/physiopathology; Syndecan-1/metabolism; Aorta/cytology; Cell Line, Tumor; Culture Media, Conditioned/pharmacology; Endothelium/pathology; Extracellular Matrix/metabolism; Heparitin Sulfate/metabolism; Humans; Multiple Myeloma/metabolism; Multiple Myeloma/pathology; Multiple Myeloma/physiopathology; Neoplasm Invasiveness; Organ Culture Techniques; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Syndecan-1 / Glucuronidase / Multiple Myeloma / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Blood Year: 2010 Type: Article Affiliation country: United States

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