Reduced nitro-oxidative stress and neural cell death suggests a protective role for microglial cells in TNFalpha-/- mice in ischemic retinopathy.

Stevenson, Laura; Matesanz, Nuria; Colhoun, Liza; Edgar, Kevin; Devine, Adrian; Gardiner, Tom A; McDonald, Denise M

Stevenson, Laura; Matesanz, Nuria; Colhoun, Liza; Edgar, Kevin; Devine, Adrian; Gardiner, Tom A; McDonald, Denise M.

Affiliation

Stevenson L; Centre for Vision and Vascular Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.

Invest Ophthalmol Vis Sci ; 51(6): 3291-9, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20107169

Subject(s)

Ischemia/metabolism; Microglia/cytology; Oxidative Stress; Retinal Diseases/metabolism; Retinal Neurons/pathology; Retinal Vessels/metabolism; Tumor Necrosis Factor-alpha/physiology; Animals; Apoptosis; Arginase/metabolism; Blotting, Western; Cell Count; Cell Death; Cell Survival; In Situ Nick-End Labeling; Ischemia/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II/metabolism; Nitrosation; Oxygen/toxicity; Reactive Nitrogen Species/metabolism; Reactive Oxygen Species/metabolism; Retinal Diseases/pathology; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine/analogs & derivatives; Tyrosine/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Diseases / Retinal Vessels / Tumor Necrosis Factor-alpha / Microglia / Oxidative Stress / Retinal Neurons / Ischemia Type of study: Prognostic_studies Limits: Animals Language: En Journal: Invest Ophthalmol Vis Sci Year: 2010 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google