Caveolin-1 mutants P132L and Y14F are dominant negative regulators of invasion, migration and aggregation in H1299 lung cancer cells.

Shatz, Maria; Lustig, Gila; Reich, Reuven; Liscovitch, Mordechai

Shatz, Maria; Lustig, Gila; Reich, Reuven; Liscovitch, Mordechai.

Affiliation

Shatz M; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel. shatzm@niehs.nih.gov

Exp Cell Res ; 316(10): 1748-62, 2010 Jun 10.

Article in En | MEDLINE | ID: mdl-20153318

Subject(s)

Caveolin 1/genetics; Caveolin 1/physiology; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Mutation, Missense; Amino Acid Substitution; Caveolae/physiology; Caveolin 1/antagonists & inhibitors; Cell Aggregation/genetics; Cell Aggregation/physiology; Cell Line, Tumor; Cell Movement/genetics; Cell Movement/physiology; Chemotaxis/genetics; Chemotaxis/physiology; Contractile Proteins/metabolism; Extracellular Matrix/physiology; Filamins; Focal Adhesion Kinase 1/metabolism; Focal Adhesions/genetics; Focal Adhesions/physiology; Humans; Lung Neoplasms/physiopathology; Metalloproteases/metabolism; Microfilament Proteins/metabolism; Microscopy, Fluorescence; Neoplasm Invasiveness/genetics; Neoplasm Invasiveness/physiopathology; Phosphorylation; RNA Interference; RNA, Small Interfering/genetics; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mutation, Missense / Caveolin 1 / Lung Neoplasms Limits: Humans Language: En Journal: Exp Cell Res Year: 2010 Type: Article Affiliation country: Israel

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