Practical synthesis of a Cathepsin S inhibitor: route identification, purification strategies, and serendipitous discovery of a crystalline salt form.

Deng, Xiaohu; Liang, Jimmy T; Peterson, Matthew; Rynberg, Raymond; Cheung, Eugene; Mani, Neelakandha S

Deng, Xiaohu; Liang, Jimmy T; Peterson, Matthew; Rynberg, Raymond; Cheung, Eugene; Mani, Neelakandha S.

Affiliation

Deng X; Johnson & Johnson Pharmaceutical Research & Development LLC, 3210 Merryfield Row, San Diego, California 92121, USA. xdeng@its.jnj.com

J Org Chem ; 75(6): 1940-7, 2010 Mar 19.

Article in En | MEDLINE | ID: mdl-20155974

Subject(s)

Cathepsins/antagonists & inhibitors; Protease Inhibitors/chemical synthesis; Protease Inhibitors/pharmacology; Crystallography, X-Ray; Drug Design; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Oxidation-Reduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Cathepsins Type of study: Diagnostic_studies Language: En Journal: J Org Chem Year: 2010 Type: Article Affiliation country: United States

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