Trp-26 imparts functional versatility to human alpha-defensin HNP1.

Wei, Gang; Pazgier, Marzena; de Leeuw, Erik; Rajabi, Mohsen; Li, Jing; Zou, Guozhang; Jung, Grace; Yuan, Weirong; Lu, Wei-Yue; Lehrer, Robert I; Lu, Wuyuan

Wei, Gang; Pazgier, Marzena; de Leeuw, Erik; Rajabi, Mohsen; Li, Jing; Zou, Guozhang; Jung, Grace; Yuan, Weirong; Lu, Wei-Yue; Lehrer, Robert I; Lu, Wuyuan.

Affiliation

Wei G; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

J Biol Chem ; 285(21): 16275-85, 2010 May 21.

Article in En | MEDLINE | ID: mdl-20220136

Subject(s)

Protein Multimerization; alpha-Defensins/chemistry; Antigens, Bacterial/genetics; Antigens, Bacterial/immunology; Antigens, Bacterial/metabolism; Bacterial Toxins/genetics; Bacterial Toxins/immunology; Bacterial Toxins/metabolism; HIV Envelope Protein gp120/genetics; HIV Envelope Protein gp120/immunology; HIV Envelope Protein gp120/metabolism; Humans; Hydrophobic and Hydrophilic Interactions; Immunity, Innate/physiology; Mutation, Missense; Protein Structure, Quaternary; Staphylococcus aureus/growth & development; Staphylococcus aureus/immunology; Staphylococcus aureus/metabolism; Structure-Activity Relationship; Tryptophan/chemistry; Tryptophan/genetics; Tryptophan/immunology; Tryptophan/metabolism; alpha-Defensins/genetics; alpha-Defensins/immunology; alpha-Defensins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpha-Defensins / Protein Multimerization Limits: Humans Language: En Journal: J Biol Chem Year: 2010 Type: Article Affiliation country: United States

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