Pharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats with acute hepatitis induced by d-galactosamine/lipopolysaccharide or CCl(4).

Kang, H E; Kim, Y W; Sohn, S I; Baek, S R; Lee, J W; Kim, S G; Lee, I; Lee, M G

Kang, H E; Kim, Y W; Sohn, S I; Baek, S R; Lee, J W; Kim, S G; Lee, I; Lee, M G.

Affiliation

Kang HE; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea.

Xenobiotica ; 40(6): 424-36, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20350053

Subject(s)

Flavanones/pharmacokinetics; Glucuronides/pharmacokinetics; Glucuronosyltransferase/metabolism; Hepatitis, Animal/drug therapy; Administration, Oral; Animals; Bile/chemistry; Blood Proteins/metabolism; Carbon Tetrachloride; Flavanones/administration & dosage; Flavanones/metabolism; Galactosamine; Glucuronides/analysis; Hepatitis, Animal/chemically induced; Hepatitis, Animal/enzymology; Injections, Intravenous; Intestines/enzymology; Lipopolysaccharides; Liver/enzymology; Male; Microsomes, Liver/metabolism; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glucuronosyltransferase / Glucuronides / Flavanones / Hepatitis, Animal Limits: Animals Language: En Journal: Xenobiotica Year: 2010 Type: Article

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