High thiopurine metabolite concentrations associated with lymphopenia in inflammatory bowel disease (IBD) pediatric patients receiving aminosalicylates combined with azathioprine.

Nguyen, T-M-H; Le Gall, C; Lachaux, A; Boulieu, R

Nguyen, T-M-H; Le Gall, C; Lachaux, A; Boulieu, R.

Affiliation

Nguyen TM; Département de Pharmacie Clinique, Pharmacocinétique et d'Evaluation du Médicament, Université de Lyon, Lyon, France.

Int J Clin Pharmacol Ther ; 48(4): 275-81, 2010 Apr.

Article in En | MEDLINE | ID: mdl-20353749

Subject(s)

Azathioprine/pharmacokinetics; Gastrointestinal Agents/pharmacokinetics; Gastrointestinal Agents/therapeutic use; Immunosuppressive Agents/pharmacokinetics; Inflammatory Bowel Diseases/metabolism; Lymphopenia/metabolism; Purines/metabolism; Salicylates/pharmacokinetics; Adolescent; Aminosalicylic Acids/adverse effects; Aminosalicylic Acids/pharmacokinetics; Aminosalicylic Acids/therapeutic use; Azathioprine/adverse effects; Azathioprine/therapeutic use; Biotransformation; Child; Child, Preschool; Drug Therapy, Combination; Erythrocytes/metabolism; Female; Gastrointestinal Agents/adverse effects; Humans; Immunosuppressive Agents/adverse effects; Immunosuppressive Agents/therapeutic use; Inflammatory Bowel Diseases/complications; Inflammatory Bowel Diseases/drug therapy; Lymphopenia/etiology; Male; Mesalamine/adverse effects; Mesalamine/pharmacokinetics; Mesalamine/therapeutic use; Salicylates/adverse effects; Salicylates/therapeutic use; Sulfasalazine/adverse effects; Sulfasalazine/pharmacokinetics; Sulfasalazine/therapeutic use

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Collection: 01-internacional Database: MEDLINE Main subject: Purines / Azathioprine / Gastrointestinal Agents / Inflammatory Bowel Diseases / Salicylates / Immunosuppressive Agents / Lymphopenia Type of study: Etiology_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: Int J Clin Pharmacol Ther Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2010 Type: Article Affiliation country: France

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