Imatinib response in two GIST patients carrying two hitherto functionally uncharacterized PDGFRA mutations: an imaging, biochemical and molecular modeling study.

Dileo, Palma; Pricl, Sabrina; Tamborini, Elena; Negri, Tiziana; Stacchiotti, Silvia; Gronchi, Alessandro; Posocco, Paola; Laurini, Erik; Coco, Paola; Fumagalli, Elena; Casali, Paolo G; Pilotti, Silvana

Dileo, Palma; Pricl, Sabrina; Tamborini, Elena; Negri, Tiziana; Stacchiotti, Silvia; Gronchi, Alessandro; Posocco, Paola; Laurini, Erik; Coco, Paola; Fumagalli, Elena; Casali, Paolo G; Pilotti, Silvana.

Affiliation

Dileo P; Department of Medical Oncology, SS Trattamento Medico dei Sarcomi dell'Adulto, Fondazione IRCCS - Istituto Nazionale Tumori, Milano, Italy. palma.dileo@istitutotumori.mi.it

Int J Cancer ; 128(4): 983-90, 2011 Feb 15.

Article in En | MEDLINE | ID: mdl-20473908

Subject(s)

Antineoplastic Agents/therapeutic use; Gastrointestinal Stromal Tumors/drug therapy; Gastrointestinal Stromal Tumors/genetics; Mutation/genetics; Piperazines/therapeutic use; Pyrimidines/therapeutic use; Receptor, Platelet-Derived Growth Factor alpha/genetics; Benzamides; Biomarkers, Tumor/metabolism; Female; Gastrointestinal Stromal Tumors/pathology; Humans; Imatinib Mesylate; Immunoenzyme Techniques; Male; Middle Aged; Models, Molecular; Positron-Emission Tomography; Prognosis; Protein Conformation; Receptor, Platelet-Derived Growth Factor alpha/chemistry; Tomography, X-Ray Computed

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyrimidines / Receptor, Platelet-Derived Growth Factor alpha / Gastrointestinal Stromal Tumors / Mutation / Antineoplastic Agents Type of study: Prognostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Int J Cancer Year: 2011 Type: Article Affiliation country: Italy

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