Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels.

Uronen, Riikka-Liisa; Lundmark, Per; Orho-Melander, Marju; Jauhiainen, Matti; Larsson, Kristina; Siegbahn, Agneta; Wallentin, Lars; Zethelius, Björn; Melander, Olle; Syvänen, Ann-Christine; Ikonen, Elina

Uronen, Riikka-Liisa; Lundmark, Per; Orho-Melander, Marju; Jauhiainen, Matti; Larsson, Kristina; Siegbahn, Agneta; Wallentin, Lars; Zethelius, Björn; Melander, Olle; Syvänen, Ann-Christine; Ikonen, Elina.

Affiliation

Uronen RL; Institute of Biomedicine/Anatomy, University of Helsinki, Finland.

Arterioscler Thromb Vasc Biol ; 30(8): 1614-20, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20489167

Subject(s)

Carrier Proteins/genetics; Cholesterol/biosynthesis; Hepatocytes/metabolism; Liver/metabolism; Membrane Glycoproteins/genetics; Niemann-Pick Disease, Type C/genetics; Polymorphism, Single Nucleotide; Proteins/genetics; Triglycerides/blood; Acetic Acid/metabolism; Aged; Animals; Cohort Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C/metabolism; Oleic Acid/metabolism; Phenotype; Proteins/metabolism; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triglycerides / Membrane Glycoproteins / Proteins / Carrier Proteins / Cholesterol / Polymorphism, Single Nucleotide / Hepatocytes / Niemann-Pick Disease, Type C / Liver Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Aged / Animals / Female / Humans / Male Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2010 Type: Article Affiliation country: Finland

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