MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.

Kolodziej, Stephen A; Hockerman, Susan L; DeCrescenzo, Gary A; McDonald, Joseph J; Mischke, Debbie A; Munie, Grace E; Fletcher, Theresa R; Stehle, Nathan; Swearingen, Craig; Becker, Daniel P

Kolodziej, Stephen A; Hockerman, Susan L; DeCrescenzo, Gary A; McDonald, Joseph J; Mischke, Debbie A; Munie, Grace E; Fletcher, Theresa R; Stehle, Nathan; Swearingen, Craig; Becker, Daniel P.

Affiliation

Kolodziej SA; Department of Medicinal Chemistry, Pfizer Research & Development, St. Louis, MO 63198, USA.

Bioorg Med Chem Lett ; 20(12): 3561-4, 2010 Jun 15.

Article in En | MEDLINE | ID: mdl-20529685

Subject(s)

Hydroxamic Acids/chemistry; Matrix Metalloproteinase Inhibitors; Administration, Oral; Amides; Animals; Hydroxamic Acids/chemical synthesis; Hydroxamic Acids/pharmacology; Inhibitory Concentration 50; Rats; Small Molecule Libraries; Solubility; Substrate Specificity; Sulfones

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Matrix Metalloproteinase Inhibitors / Hydroxamic Acids Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States

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