Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.

Kertesz, Denis J; Brotherton-Pleiss, Christine; Yang, Minmin; Wang, Zhanguo; Lin, Xianfeng; Qiu, Zongxing; Hirschfeld, Donald R; Gleason, Shelley; Mirzadegan, Taraneh; Dunten, Pete W; Harris, Seth F; Villaseñor, Armando G; Hang, Julie Qi; Heilek, Gabrielle M; Klumpp, Klaus

Kertesz, Denis J; Brotherton-Pleiss, Christine; Yang, Minmin; Wang, Zhanguo; Lin, Xianfeng; Qiu, Zongxing; Hirschfeld, Donald R; Gleason, Shelley; Mirzadegan, Taraneh; Dunten, Pete W; Harris, Seth F; Villaseñor, Armando G; Hang, Julie Qi; Heilek, Gabrielle M; Klumpp, Klaus.

Affiliation

Kertesz DJ; Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. deniskertesz@comcast.net

Bioorg Med Chem Lett ; 20(14): 4215-8, 2010 Jul 15.

Article in En | MEDLINE | ID: mdl-20538456

Subject(s)

HIV Reverse Transcriptase/antagonists & inhibitors; HIV-1/drug effects; Mutation; Pyrimidines/pharmacology; Reverse Transcriptase Inhibitors/pharmacology; Drug Discovery; Drug Resistance, Viral/genetics; HIV-1/genetics; Models, Molecular; Pyrimidines/chemistry; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / HIV-1 / Reverse Transcriptase Inhibitors / HIV Reverse Transcriptase / Mutation Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States

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