Celiac anti-tissue transglutaminase antibodies interfere with the uptake of alpha gliadin peptide 31-43 but not of peptide 57-68 by epithelial cells.

Caputo, Ivana; Barone, Maria Vittoria; Lepretti, Marilena; Martucciello, Stefania; Nista, Ivan; Troncone, Riccardo; Auricchio, Salvatore; Sblattero, Daniele; Esposito, Carla

Caputo, Ivana; Barone, Maria Vittoria; Lepretti, Marilena; Martucciello, Stefania; Nista, Ivan; Troncone, Riccardo; Auricchio, Salvatore; Sblattero, Daniele; Esposito, Carla.

Affiliation

Caputo I; Department of Chemistry, University of Salerno, Italy.

Biochim Biophys Acta ; 1802(9): 717-27, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20553859

Subject(s)

Autoantibodies/pharmacology; Celiac Disease/immunology; Epithelial Cells/drug effects; Gliadin/pharmacokinetics; Transglutaminases/antagonists & inhibitors; Transglutaminases/immunology; Caco-2 Cells; Celiac Disease/metabolism; Drug Antagonism; Endocytosis/drug effects; Endocytosis/immunology; Enzyme Activation/drug effects; Epithelial Cells/metabolism; Gliadin/chemistry; Gliadin/pharmacology; Humans; Intestinal Mucosa/drug effects; Intestinal Mucosa/metabolism; Peptide Fragments/chemistry; Peptide Fragments/pharmacokinetics; Peptide Fragments/pharmacology; S Phase/drug effects; Transglutaminases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Celiac Disease / Transglutaminases / Epithelial Cells / Gliadin Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2010 Type: Article Affiliation country: Italy

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