Exploration of a new series of CCR5 antagonists: multi-dimensional optimization of a sub-series containing N-substituted pyrazoles.

Lemoine, Rémy C; Petersen, Ann C; Setti, Lina; Jekle, Andreas; Heilek, Gabrielle; deRosier, André; Ji, Changhua; Berry, Pamela; Rotstein, David M

Lemoine, Rémy C; Petersen, Ann C; Setti, Lina; Jekle, Andreas; Heilek, Gabrielle; deRosier, André; Ji, Changhua; Berry, Pamela; Rotstein, David M.

Affiliation

Lemoine RC; Department of Medicinal Chemistry, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. remy_lemoine@yahoo.com

Bioorg Med Chem Lett ; 20(16): 4753-6, 2010 Aug 15.

Article in En | MEDLINE | ID: mdl-20643548

Subject(s)

Anti-HIV Agents/chemistry; CCR5 Receptor Antagonists; Pyrazoles/chemistry; Anti-HIV Agents/chemical synthesis; Anti-HIV Agents/pharmacology; Humans; Pyrazoles/chemical synthesis; Pyrazoles/pharmacology; Receptors, CCR5/metabolism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Anti-HIV Agents / CCR5 Receptor Antagonists Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States

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