Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway.

Luo, Cheng-Liang; Chen, Xi-Ping; Yang, Rui; Sun, Yu-Xia; Li, Qian-Qian; Bao, Hai-Jun; Cao, Qiang-Qiang; Ni, Hong; Qin, Zheng-Hong; Tao, Lu-Yang

Luo, Cheng-Liang; Chen, Xi-Ping; Yang, Rui; Sun, Yu-Xia; Li, Qian-Qian; Bao, Hai-Jun; Cao, Qiang-Qiang; Ni, Hong; Qin, Zheng-Hong; Tao, Lu-Yang.

Affiliation

Luo CL; Department of Forensic Medicine, Soochow University, Suzhou, China.

J Neurosci Res ; 88(13): 2847-58, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20653046

Subject(s)

Apoptosis/physiology; Brain Injuries/metabolism; Brain Injuries/physiopathology; Cathepsin B/metabolism; Mitochondria/physiology; Up-Regulation/physiology; Animals; Apoptosis/drug effects; Brain Injuries/drug therapy; Cathepsin B/antagonists & inhibitors; Chaperonin 60/metabolism; Cyclooxygenase 2/metabolism; Disease Models, Animal; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Glial Fibrillary Acidic Protein/metabolism; Maze Learning/drug effects; Mice; Mitochondria/drug effects; Motor Activity/drug effects; Motor Activity/physiology; Proto-Oncogene Proteins c-bcl-2/metabolism; Statistics, Nonparametric; Time Factors; Up-Regulation/drug effects

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Injuries / Cathepsin B / Up-Regulation / Apoptosis / Mitochondria Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Res Year: 2010 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google