Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes.

Wang, Michael L; Motamed, Massoud; Infante, Rodney E; Abi-Mosleh, Lina; Kwon, Hyock Joo; Brown, Michael S; Goldstein, Joseph L

Wang, Michael L; Motamed, Massoud; Infante, Rodney E; Abi-Mosleh, Lina; Kwon, Hyock Joo; Brown, Michael S; Goldstein, Joseph L.

Affiliation

Wang ML; Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

Cell Metab ; 12(2): 166-73, 2010 Aug 04.

Article in En | MEDLINE | ID: mdl-20674861

Subject(s)

Carrier Proteins/metabolism; Cholesterol/metabolism; Glycoproteins/metabolism; Lysosomes/metabolism; Membrane Glycoproteins/metabolism; Alanine/chemistry; Alanine/metabolism; Amino Acid Substitution; Animals; Binding Sites; Biological Transport; CHO Cells; Cricetinae; Cricetulus; Humans; Hydrophobic and Hydrophilic Interactions; Intracellular Signaling Peptides and Proteins; Mutagenesis; Niemann-Pick C1 Protein; Protein Structure, Tertiary; Vesicular Transport Proteins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Glycoproteins / Carrier Proteins / Cholesterol / Lysosomes Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2010 Type: Article Affiliation country: United States

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