Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome.

Locke, Adam E; Dooley, Kenneth J; Tinker, Stuart W; Cheong, Soo Yeon; Feingold, Eleanor; Allen, Emily G; Freeman, Sallie B; Torfs, Claudine P; Cua, Clifford L; Epstein, Michael P; Wu, Michael C; Lin, Xihong; Capone, George; Sherman, Stephanie L; Bean, Lora J H

Locke, Adam E; Dooley, Kenneth J; Tinker, Stuart W; Cheong, Soo Yeon; Feingold, Eleanor; Allen, Emily G; Freeman, Sallie B; Torfs, Claudine P; Cua, Clifford L; Epstein, Michael P; Wu, Michael C; Lin, Xihong; Capone, George; Sherman, Stephanie L; Bean, Lora J H.

Affiliation

Locke AE; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.

Genet Epidemiol ; 34(6): 613-23, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20718043

Subject(s)

Down Syndrome/epidemiology; Down Syndrome/genetics; Folic Acid/genetics; Heart Defects, Congenital/epidemiology; Heart Defects, Congenital/genetics; Black People/genetics; Black People/statistics & numerical data; Case-Control Studies; Causality; Chromosomes, Human, Pair 21/genetics; Comorbidity; Genetic Association Studies; Genetic Variation; Genotype; Heart Septal Defects/epidemiology; Heart Septal Defects/genetics; Humans; Incidence; Polymorphism, Single Nucleotide; White People/genetics; White People/statistics & numerical data

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down Syndrome / Folic Acid / Heart Defects, Congenital Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Genet Epidemiol Journal subject: EPIDEMIOLOGIA / GENETICA MEDICA Year: 2010 Type: Article Affiliation country: United States

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