Peptides derived from the CDR3-homologous domain of the CD4 molecule are specific inhibitors of HIV-1 and SIV infection, virus-induced cell fusion, and postinfection viral transmission in vitro. Implications for the design of small peptide anti-HIV therapeutic agents.

Rausch, D M; Hwang, K M; Padgett, M; Voltz, A H; Rivas, A; Engleman, E; Gaston, I; McGrath, M; Fraser, B; Kalyanaraman, V S

Rausch, D M; Hwang, K M; Padgett, M; Voltz, A H; Rivas, A; Engleman, E; Gaston, I; McGrath, M; Fraser, B; Kalyanaraman, V S.

Affiliation

Rausch DM; Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892.

Ann N Y Acad Sci ; 616: 125-48, 1990.

Article in En | MEDLINE | ID: mdl-2078014

Subject(s)

Acquired Immunodeficiency Syndrome/immunology; CD4 Antigens/immunology; Immunoglobulin Variable Region/immunology; Simian Acquired Immunodeficiency Syndrome/immunology; Acquired Immunodeficiency Syndrome/transmission; Amino Acid Sequence; Animals; Antiviral Agents/immunology; CD4 Antigens/chemistry; Cell Fusion/immunology; Drug Design; Immunoglobulin Variable Region/chemistry; Molecular Sequence Data; Simian Acquired Immunodeficiency Syndrome/transmission

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Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Variable Region / CD4 Antigens / Simian Acquired Immunodeficiency Syndrome / Acquired Immunodeficiency Syndrome Type of study: Prognostic_studies Limits: Animals Language: En Journal: Ann N Y Acad Sci Year: 1990 Type: Article

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