Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells.

Caddy, J; Isa, S; Mainwaring, L S; Adam, E; Roberts, A; Lang, D; Morris, R H K; Thomas, A W; Webb, R

Caddy, J; Isa, S; Mainwaring, L S; Adam, E; Roberts, A; Lang, D; Morris, R H K; Thomas, A W; Webb, R.

Affiliation

Caddy J; Centre for Biomedical Sciences, Cardiff School of Health Sciences, University of Wales Institute Cardiff, Cardiff CF5 2YB, UK.

Biochem Biophys Res Commun ; 400(4): 689-95, 2010 Oct 01.

Article in En | MEDLINE | ID: mdl-20816668

Subject(s)

Hypoglycemic Agents/pharmacology; Monocytes/drug effects; Muscle, Smooth, Vascular/drug effects; Myocytes, Smooth Muscle/drug effects; Thiazolidinediones/pharmacology; Unfolded Protein Response; Vasodilator Agents/pharmacology; Calcium/metabolism; Cell Line; Cell Survival/drug effects; DNA-Binding Proteins/metabolism; Endoplasmic Reticulum Chaperone BiP; Gene Expression/drug effects; Heat-Shock Proteins/genetics; Heat-Shock Proteins/metabolism; Homeostasis/drug effects; Humans; Monocytes/metabolism; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/metabolism; Regulatory Factor X Transcription Factors; Rosiglitazone; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism; Thiazolidinediones/adverse effects; Transcription Factors/metabolism; X-Box Binding Protein 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasodilator Agents / Monocytes / Myocytes, Smooth Muscle / Thiazolidinediones / Unfolded Protein Response / Hypoglycemic Agents / Muscle, Smooth, Vascular Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2010 Type: Article Affiliation country: United kingdom

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