4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.

Liu, Kevin K-C; Bagrodia, Shubha; Bailey, Simon; Cheng, Hengmiao; Chen, Hui; Gao, Lisa; Greasley, Samantha; Hoffman, Jacqui E; Hu, Qiyue; Johnson, Ted O; Knighton, Dan; Liu, Zhengyu; Marx, Matthew A; Nambu, Mitchell D; Ninkovic, Sacha; Pascual, Bernadette; Rafidi, Kristina; Rodgers, Caroline M-L; Smith, Graham L; Sun, Shaoxian; Wang, Haitao; Yang, Anle; Yuan, Jing; Zou, Aihua

Liu, Kevin K-C; Bagrodia, Shubha; Bailey, Simon; Cheng, Hengmiao; Chen, Hui; Gao, Lisa; Greasley, Samantha; Hoffman, Jacqui E; Hu, Qiyue; Johnson, Ted O; Knighton, Dan; Liu, Zhengyu; Marx, Matthew A; Nambu, Mitchell D; Ninkovic, Sacha; Pascual, Bernadette; Rafidi, Kristina; Rodgers, Caroline M-L; Smith, Graham L; Sun, Shaoxian; Wang, Haitao; Yang, Anle; Yuan, Jing; Zou, Aihua.

Affiliation

Liu KK; Pfizer Global Research and Development, Chemistry Department, La Jolla, CA 92120, USA. kevin.k.liu@pfizer.com

Bioorg Med Chem Lett ; 20(20): 6096-9, 2010 Oct 15.

Article in En | MEDLINE | ID: mdl-20817449

Subject(s)

Antineoplastic Agents/chemistry; Antineoplastic Agents/therapeutic use; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/therapeutic use; Pteridines/chemistry; Pteridines/therapeutic use; TOR Serine-Threonine Kinases/antagonists & inhibitors; Administration, Oral; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/pharmacology; Cell Line, Tumor; Glioma/drug therapy; Humans; Mice; Models, Molecular; Neoplasms/drug therapy; Phosphatidylinositol 3-Kinases/chemistry; Phosphatidylinositol 3-Kinases/metabolism; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/pharmacology; Pteridines/administration & dosage; Pteridines/pharmacology; Solubility; Structure-Activity Relationship; TOR Serine-Threonine Kinases/chemistry; TOR Serine-Threonine Kinases/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pteridines / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases / Phosphoinositide-3 Kinase Inhibitors / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google