Epigenetic control of recombination in the immune system.
Semin Immunol
; 22(6): 323-9, 2010 Dec.
Article
in En
| MEDLINE
| ID: mdl-20832333
ABSTRACT
Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Recombination, Genetic
/
Epigenomics
/
Immune System
Limits:
Animals
/
Humans
Language:
En
Journal:
Semin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2010
Type:
Article
Affiliation country:
Israel