Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis.

Mazzoleni, Stefania; Politi, Letterio S; Pala, Mauro; Cominelli, Manuela; Franzin, Alberto; Sergi Sergi, Lucia; Falini, Andrea; De Palma, Michele; Bulfone, Alessandro; Poliani, Pietro L; Galli, Rossella

Mazzoleni, Stefania; Politi, Letterio S; Pala, Mauro; Cominelli, Manuela; Franzin, Alberto; Sergi Sergi, Lucia; Falini, Andrea; De Palma, Michele; Bulfone, Alessandro; Poliani, Pietro L; Galli, Rossella.

Affiliation

Mazzoleni S; Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

Cancer Res ; 70(19): 7500-13, 2010 Oct 01.

Article in En | MEDLINE | ID: mdl-20858720

Subject(s)

ErbB Receptors/biosynthesis; Glioblastoma/enzymology; Neoplastic Stem Cells/enzymology; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic/metabolism; Cell Transformation, Neoplastic/pathology; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/genetics; Gene Silencing; Gene Transfer Techniques; Glioblastoma/genetics; Glioblastoma/pathology; Humans; Mice; Mice, Nude; Neoplastic Stem Cells/pathology; Quinazolines; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Tyrphostins/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Glioblastoma / ErbB Receptors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2010 Type: Article Affiliation country: Italy

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